NIMG-19. IMAGE-BASED MODELING MAP OF EDEMA IS CORRELATED WITH MULTIPLE BLOOD-BRAIN-BARRIER PERMEABILITY RELEVANT TRANSCRIPTOMIC MARKERS IN BRAIN TUMOR PATIENTS

Abstract Brain tumor associated edema is a significant cause of patient morbidity and mortality often requiring continual treatment with differing levels success across patients. Edema broad term that can indicate increased local water as well diffusely infiltrating cells. visualized hyperintense regions on T2-weighted (T2W) magnetic resonance imaging (MRI) typically blood-brain barrier (BBB) breakdown aggressiveness. Understanding the molecular mechanisms driving patterns “edema” could provide insights into clinical interpretation. We have an ongoing image-guided biopsy study allows us to link markers locoregional MRI edema. Further, we previously developed physics-based method estimate abundance (i.e., map) from T2W MRIs. Our goal was identify connections between BBB-associated factors in brain tumors. cohort included 38 patients (female: 15, male: 23) 129 biopsies 62, 67). correlated image-localized map values mean transcriptional frequency for 57 genes related BBB function. Additionally, examined correlations separately according reported sex male female) phenotype ENH: enhancing NE: non-enhancing). utilized multiple comparisons corrections 5% false discovery rate determine significance. For overall cohort, observed positive HIF1A (p< 0.001) SOX2 NE samples, APOE (p=0.001), 0.001), PIK3CA PTCH1 0.001). Amongst female correlation (p=0.002) observed. There were no noted sub-cohorts. Significant lead biomarkers or